• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    An improved centrifuge assembly comprising a channeled rotor assembly and a fluid container disposed in the channel, whereby the centrifugal separation effects in the fluid container are determined by the geometry of the channel in the rotor. This arrangement is particularly useful for two-stage blood platelet separation. The fluid container is preferably formed from semirigid plastic material and is considered a disposable item to be discarded after a single use. The rotary assembly preferably includes a removable filler piece or center piece formed from a single piece of material, such as rigid plastic, as by machining or molding, and having therein an open-topped channel having dimensions appropriate to receive the semirigid container, which is suitably curved and placed in the channel. Fluid connections are provided from each end of the container and an intermediate point to an axially located multichannel rotating seal. The connections lie in a plurality of radial slots in the filler piece. The channel is divided into two distinct portions, the first portion of the channel being circular with a constant radius, and the second portion being spiral and having a plurality of radiuses, each measured from a different center, the spiral increasing radially outward from its juncture with the first stage. The intermediate fluid connection is established near the junction of the first stage and the second stage. The spiral portion of the channel and container may have an outward slope from bottom to top.
    公开号:SU1058490A3
    申请号:SU782667700
    申请日:1978-09-28
    公开日:1983-11-30
    发明作者:Мелрой Келлог Роберт；Пауль Мульзет Альфред
    申请人:Интернэшнл Бизнес Машинз Корпорейшн (Фирма)；
    IPC主号:
    专利说明:

    The invention relates to a centrifuge centrifuge and can be used in medicine. A known centrifuge for the separation of blood into fractions, containing a rotor with an elastic material insert that has a separation channel for the plasma and equipped with tubes for draining the separated fractions. A disadvantage of the known centrifuge is its small capacity. Ilej | b of the invention - increased centrifuge productivity. To achieve this goal, in a centrifuge to separate the blood into fractions containing a rotor with an insert made of elastic material, having a separation channel for blood and equipped with tubes for draining the separated fractions, the rotor is made in the form of a disk with an open shaped channel for | inserts in it, having sections made in an arc and spirals with a radius increasing in the direction of blood flow and connected by a straight line section, while the cross-sectional area of the figure channel formed in a spiral is one-fourth of the cross-sectional area , made in an arc, and the insert has a shape similar to that of a shaped channel. The insert must be provided with an assembly chamber attached to it, while the inlet sections of the Discharge Fraction tubes are located in the chamber at different distances from the axis of rotation. The disc must have radial slots communicating with the Figured channel to accommodate the collection chamber and the Pipes. Figure 1 and 2 depict the rotor and the insert in a perspective view; fyg.Z rotor, top view; figure 4 is a section aa on fig.Z; figure 5 is a rotor, a longitudinal section; figure 6 - part of the channel figure. I A centrifuge for separating blood into fractions contains a rotor made in the form of a disk 1 with an open shaped channel 2 for placing an insert 3 of elastic material in it, made in the form of a hollow ring having a blood separator KaHajq inside and fitted with tubes 4 blood and removal of red blood cell fractions, plasma and white blood cells. The figure channel 2 has sections 8 and 9, made in the shape of an arc and drank with a magnification in the direction of blood with a radius and connected by a straight line; section 10 The cross-sectional area of the section of the shaped channel, which is made in a spiral, is the fourth part of the cross-sectional area of the section, which is made along an arc. The insert 3 has a form similar to the shape of the shaped channel 2, and is equipped with an attached chamber 11, while the inlet sections of the tubes 5-7 for - draining the fractions are located in the chamber at different distances. from the axis of rotation, the disk 1 has a central hole 12 and a radial spline 13 which communicates with the shaped channel 2 to accommodate the collecting chamber and tubes 4-7. The disk has: holes 14 that serve to balance it and remove the disk from the housing 15. Section A 9 shaped channel, formed in a spiral, is formed by ps, adiuses 16, 17, or 18, drawn from centers 19, 20, or 21. The lateral surface of the disk is located along arcs 22, 23 i, or 24, extending more than 180 °, Section 9 of figured the channel and the insert along the arcs 22 and 23 have an outer slope of about 8 °. On the segment of Arc 24 of this bias is no longer. The disk 1 can be made integral with the case (figure 5) in case the disk change is not required. In that case, if the slope of the section 9 of the shaped channel is not required, this section can be made without a slope, vertical (Fig. 6). The insert 3 is made primarily of disposable semi-rigid plastic. The tubes 4-7 are connected to a device 25 for the blood supply and discharge of the separated fractions consisting of stationary and rotating disk elements. The centrifuge works as follows. An insert 3 is installed in the open-top shaped channel 2 of the disk 1. The tubes 4-7 are connected to a rotating disk element of the device 25, the rigid connecting pipes of which (not shown) lead to an apparatus, such as a medical device for treating individual blood fractions. The device 25 is located in the central hole 12 of the disk 1. Tubes 4-7 are inserted into the corresponding slots 13 of the disk 1. Separable blood through the device 25 and the tube 4 is fed into the arcuate section of the insert 3. When the rotor rotates, dense fractions of blood (red blood cells ) are dropped to the outer walls of the arcuate portion of the insert 3. In this first portion of the channel,
    layers, and over dense fraction (in the direction of the axis of rotation) with red blood cells, blood is harvested on a liquid or blasted plasma, which also contains other fractions, such as white blood cells.
    In order to achieve complete separation of the types of blood cells, first of all, the red blood cell fraction is selected as completely as possible through the tube 5 at the end of the arcuate portion of the insert. The inlet of tube 5 is located at the wall of the insert, therefore only red blood cells are selected.
    The rate of flow of red blood cells needs to be adjusted so that only enriched plasma can penetrate into the second part of the channel, which in the spiral-like part is divided into cell plasma and white blood cells. In order to ensure a sufficient fluid velocity in the second part of the channel for the removal of a smaller part of the original blood, the cross section of the channel there is accordingly reduced. In addition, the beam is spiraling with increasing radius, thereby maintaining the centrifugal effect. The inward rectilinear section of the channel of the insert 3 forms a transitional part between the arcuate and spiral-shaped parts of the channel. Since this area is inward, it prevents the red blood cells from flowing in
    In this case, while the rate at which red blood cells flow through tube 5 is regulated, to this end, service personnel must clearly distinguish the boundary layer between the red blood cells and the enriched one. plasma in the transitional part. With stroboscopic illumination, t, e, of light flashes synchronous with the speed of rotation of the centrifuge,
    0, it is possible to ensure that for the observer the rotating disk 1 of the centrifuge appears stationary. The staff in this case clearly sees the position of the boundary layer and
    5 can appropriately regulate the flow rate of red blood cells,
    The plasma is collected at the end of the spiral-shaped part in the collecting chamber 11 of the insert 3. There are formed layers, and a dense concentrate of white cells is collected outside, and above it a layer devoid of cells,
    The proposed centrifuge is economical to manufacture and makes it possible to use simple vessels for disposable fluid, thereby reducing the cost of cleaning and sterilization.
    0
    The separation of fractions inside a liquid vessel in a centrifuge is greatly facilitated with a ps geometry of the channel in the rotor. The design is especially valuable for a two-stage
    5 separation of blood cells.
    The design of the centrifuge rotor allows to increase its productivity in comparison with the known.
    t
    -13
    12
    15
    P
    . 13
    Fia. 2
    H.v.
    权利要求:
    Claims (3)
    [1]
    1. CENTRIFUGA FOR SEPARATION OF BLOOD IN FRACTION, containing a rotor with an insert of elastic material located in it, having a separation channel for blood and equipped with tubes for draining the separated fractions, distinguishing me in that, in order to increase productivity, the rotor made in the form of a disk with an open figured channel for insertion in it, having sections made along an arc and spiral with a radius increasing in the direction * of blood movement and connected by a straight section, while the cross-sectional area figure channel section taken along the spiral is one fourth of the cross sectional portion formed in an arc, wherein the insert has a shape similar to figure channel.
    [2]
    2. The centrifuge according to claim 1, with the fact that the insert is equipped with a collection chamber attached to it, while the inlet sections of the tubes for removing fractions are located in the chamber at different distances ~ from the axis of rotation.
    [3]
    3. Centrifuge on π. 1, with the fact that the disk has radial slots in communication with the figured channel for accommodating the collection chamber and tubes.
    类似技术:
    公开号 | 公开日 | 专利标题
    SU1058490A3|1983-11-30|Centrifuge for separating blood in fractions
    US4386730A|1983-06-07|Centrifuge assembly
    CA1206937A|1986-07-02|Centrifuge assembly
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    US4010894A|1977-03-08|Centrifuge fluid container
    US4636193A|1987-01-13|Disposable centrifugal blood processing system
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    US4278202A|1981-07-14|Centrifuge rotor and collapsible separation container for use therewith
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    US6855102B2|2005-02-15|Method for separating cells, especially platelets, and bag assembly therefor
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    US5217427A|1993-06-08|Centrifuge assembly
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    EP0299054B1|1993-10-13|Centrifugation pheresis system
    EP0285891A2|1988-10-12|Blood centrifugation cell
    AU596287B2|1990-04-26|Continuous blood centrifugation cell
    ES2248948T3|2006-03-16|CENTRIFUGE CAMERA FOR A CELL SEPARATOR.
    US5571068A|1996-11-05|Centrifuge assembly
    EP0664159A1|1995-07-26|Plural collector centrifuge bowl for blood processing
    IL51629A|1979-11-30|Disposable centrifugal blood processing system
    CA1159803A|1984-01-03|Centrifuge assembly
    同族专利:
    公开号 | 公开日
    FR2404470A1|1979-04-27|
    IT1110162B|1985-12-23|
    GB1572337A|1980-07-30|
    FR2404470B1|1982-10-01|
    DE2821055A1|1979-04-12|
    IT7827916D0|1978-09-21|
    US4387848A|1983-06-14|
    JPS5731467B2|1982-07-05|
    ZA783523B|1980-02-27|
    CH630540A5|1982-06-30|
    ES473847A1|1979-10-16|
    DE2821055C2|1987-05-14|
    JPS5727156A|1982-02-13|
    JPS5454375A|1979-04-28|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    US05/839,156|US4387848A|1977-10-03|1977-10-03|Centrifuge assembly|
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